Tumor cells secrete small vesicles named exosomes which are involved in tumor stroma communication as well as in disease development and progression. Tumor-derived exosomes harbor a variety of proteins, nucleic acids, and lipids and are present in all body fluids. Exosomes draw much attention as a promising biomarker for tumor diagnosis and prognosis.

This project aims to identify potential biomarkers in exosomes derived from murine preclinical models and cells of patients affected by hematologic malignancies and to test their influence on cells from the microenvironment. Candidates showing the greatest potential to be used in personalized medicine will be validated in cohorts of patients.

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Project financed by the Fonds National de la Recherche Luxembourg (grants INTER/DFG/16/11509946 and PRIDE15/10675146/CANBIO)

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Dr. Martina Seiffert   undefined

Dr. Daniel Mertens   undefined

Pr. Eric Solary      undefined

Pr. Patrick Auberger   undefined

 

Moussay et al, PNAS 2011

Paggetti et al, Blood 2015

Wierz et al, Meth Mol Biol 2018

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