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14:00 - 19:00 Registration open
17:00 - 17:30 Welcome
17:30 - 18:30 Keynote Lecture
Chairperson: Markus Ollert
Speaker: Jean-Laurent Casanova: "Toward a genetic theory of childhood infectious diseases”
19:00 Welcome Cocktail
Chairpersons: Thierry Walzer, Domenico Mavilio
- 08:30 - 08:50 Katharine Hsu: "New insights to old ideas in NK education"
- 08:50 - 09:10 Jacques Zimmer: "Imprint of education on activated natural killer cells"
- 09:10 - 09:20 Selected short talk 1 - Sytse Piersma: “Activation Receptor-dependent IFNγ Production by NK Cells is Controlled by Transcription, Translation and the Proteasome”
- 09:20 - 09:40 Peter Parham: “Interactions of KIR, HLA class I and Disease”
- 09:40 - 10:00 Karl-Johan Malmberg: "Functional diversification of human NK cells through lysosomal maturation and remodeling"
Chairpersons: Aharon Freud, Cynthia Dunbar
-10:30 - 10:50 Catherine Blish: “Tuning the human natural killer response to viral infection”
-10:50 - 11:00 Selected short talk 2 - Bethany Mundy-Bosse : “Epigenetic Dysregulation of EBV(+) Extranodal NK/T cell Lymphoma Defines Distinct Subsets of Disease”
-11:00 - 11:20 Emily Mace: “New insights into requirements for adhesion and migration in human NK cell development”
-11:20 - 11:30 Selected short talk 3 - Geoffrey Guittard: ”Targeting CIS in NK cells improves their anti-tumor functions without impairing homeostasis”
-11:30 - 11:50 Michael A. Caligiuri: "A missing link: Why PD-L1 negative tumors respond to anti-PD-L1"
-11:50 - 12:00 Selected short talk 4 - Philippa Kennedy: ”A tri-specific killer engager (TriKE) against mesothelin targets NK cells towards lung cancer”
Chairpersons: Nathalie Jacobs, Evelyn Ullrich
-13:30 - 13:50 Mariapia Degli-Esposti: “NK cell regulation of inflammatory responses”
-13:50 - 14:10 Christian Vosshenrich: “ILC development – from a T cell perspective”
-14:10 - 14:20 Selected short talk 5 - Selma Boulenouar: “High-fat diet causes rapid microbiota-dependent intestinal ILC3 loss and impairs tolerance and immunity”
-14:20 - 14:40 Marco Colonna: "NCRs Ligands"
-14:40 - 15:00 Andreas Diefenbach: “Control of tissue homeostasis and growth by innate lymphoid cells”
Chairpersons: Sophie Ugolini, Dirk Brenner
-15:30 - 15:50 Greta Guarda: “Novel mechanisms regulating NK cell immunity”
-15:50 - 16:00 Selected short talk 6 - Luana Guerra: “Glutathione modulates Natural Killer cell function”
-16:00 - 16:20 Clair M. Gardiner: “How cancer impacts on NK cell metabolism”
-16:20 - 16:30 Selected short talk 7 - Andrew Highton: ”Distinct Metabolic Profiles in Differentially Educated NK Cell Populations”
-16:30 - 16:50 Megan A. Cooper: “Metabolic regulation of NK cell anti-viral functions”
-16:50 - 17:00 Selected short talk 8 - Laurent Brossay: “KLRG1 as a novel checkpoint inhibitor target“
Chairpersons: Massimo Vitale, Christian Vosshenrich
-08:30 - 08:50 Adelheid Cerwenka: “Exploiting Natural Killer cell functional heterogeneity in cancer“
-08:50 - 09:10 David H. Raulet: "NK cell activation and inactivation in the tumor microenvironment: Potential for mobilizing NK cells for cancer therapy”
-09:10 - 09:20 Selected short talk 9 - Karoliina Tuomela: ”Radiotherapy induces resistance to NK cell cytotoxicity”
-09:20 - 09:40 Jordan S. Orange: “Advances in the mechanics of NK cell cytotoxicity”
-09:40 - 10:00 Carsten Watzl: “Insights into the cytotoxic mechanisms of NK cells“
Chairpersons: Frank Cichocki, Yenan Bryceson
-10:30 - 10:50 Joseph C. Sun: "Molecular mechanisms controlling adaptive NK cell responses"
-10:50 - 11:00 Selected short talk 10 - Endi Santosa:” Themis2 regulates innate and adaptive lymphocyte responses during viral infection”
-11:00 - 11:20 Silke Paust: "NK memory to HIV"
-11:20 - 11:30 Selected short talk 11 -Vanda Juranic Lisnic: “Altered-self MHC I molecules in MCMV evasion of NK cells and evolution of virus-specific Ly49 receptors”
-11:30 - 11:50 Todd A. Fehniger: "Cytokine-Induced Memory-Like NK cells"
-11:50 - 12:00 Selected short talk 12 - Alvaro Haroun-Izquierdo: “Efficient Scale-up and Pre-clinical Evaluation of NKG2C+ Adaptive NK Cell Expansion for Therapy Against High-risk AML/MDS”
Chairpersons: Angela Santoni, Bassam Janji
-13:30 - 13.50 Eric Vivier: “Manipulation of Natural Killer cells in Cancer”
-13:50 - 14:10 Kathy Rezvani: “Next generation engineered NK cell therapies for the treatment of cancer”
-14:10 - 14:20 Selected short talk 13 - Pauline Rettman :” A DNA vaccine targeting KIR2DS2 activates NK cells and inhibits tumour growth”
-14:20 - 14:40 Winfried Wels: ”CAR-engineered NK cells: Off-the-shelf therapeutics bridging innate and adaptive immunity”
-14:40 - 15:00 Zhigang Tian: “NK Cell Exhaustion and Reversal in Tumor Immunotherapy”
Chairpersons: Ana Stojanovic, Niklas Björkström
-08:30 - 08:50 Wayne Yokoyama: “Tissue-resident NK cells in the pregnant uterus.”
-08:50 - 09:00 Selected short talk 14 - Anaïs Eberhardt: “Interleukin-33 is a novel activator of a subset of polyfunctional NK cells with anti-tumor activity”
-09:00 - 09:10 Selected short talk 15 - Ayad Ali: ”A LAGging sensation prevents overexuberant immune regulation by splenic NK cells
-09:10 - 09:20 Selected short talk 16 - John Sunwoo: ”Heterogeneity of NK Cells and Innate Lymphoid Cells in the Tissue Microenvironment of Human Tumors”
-09:20 - 09:40 Ashley Moffett. “On the Frontier: No Hard Border between the Mother and her Fetus”
-09:40 - 09:50 Selected short talk 17 - Ana Espino: ”Interplay between Zika Virus and Decidual Natural Killer cells at the human maternal-fetal interface”
-09:50 - 10:00 Selected short talk 18 - Silvia Pesce: “Relevant role for PD-1 immune checkpoint expressed on NK cells derived from ovarian cancer patients”
Chairpersons: Eleanor Riley, Stipan Jonjic
-10:30 - 10:50 Chiara Romagnani: “CMV imprinting of NK cells signatures”
-10:50 - 11:10 Lewis L. Lanier: “NK cell interaction with MHC class I-negative cells”
-11:10 - 11:20 Selected short talk 19 - Helen Wagstaffe: ” Ebola Virus Glycoprotein Stimulates IL-18 Dependent Natural Killer Cell Responses”
-11:20 - 11:40 Marcus Altfeld: “Regulation of NK cell activation by HLA class II and non-classical HLA class I”
-11:40 - 12:00 Christopher H. Mody: "Direct fungal killing by human NK cells"
Chairpersons: Nick Huntington, Salim Khakoo
-13:30 - 13:50 Ulrike Köhl: “CAR expressing NK cells for cancer retargeting”
-13:50 - 14:10 Jeffrey Miller: "Enhancing NK Cell Specificity With Off-the-Shelf engagers (TrIKEs) and iPS derived NK"
-14:10 - 14:20 Selected short talk 20 - Aura Muntasell : ”Predictive value of tumor-associated and circulating NK cells for neoadjuvant therapy response in primary HER2-positive breast cancer patients”
-14:20 - 14:40 Dean Lee: “Genetic, epigenetic, and non-genetic reprogramming of NK cells for therapeutic application”
-14:40 - 15:00 Hans Gustaf Ljunggren: ”Autologous NK cell-based adoptive immunotherapies in human lymphoid malignancies”
The 18th Meeting of the Society for Natural Immunity (SNI) is organized by the SNI and the Luxembourg Institute of Health
