Joseph Longworth

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Scientist, “RPPA platform”

Quantitative Biology Unit (QBU)

+352 26 970 382

joseph.longworth@lih.lu

Research Experience

2019 - Present: Head of Platform - Reverse Phase Protein Array

Luxembourg Institute of Health

2017- 2019: Post Doctoral fellowship -Luxembourg Clinical proteomics unit

Luxembourg Institute of Health

2007 - 2017: Research Associate in Quantitative Proteomics 

The University of Sheffield, UK

2009 - 2012: PhD Proteomics in microalgae: a postgenomic approach for improved biofuel production

The University of Sheffield, UK

Publications

van Well, E. M.; Bader, V.; Patra, M.; Sánchez-Vicente, A.; Meschede, J.; Furthmann, N.; Schnack, C.; Blusch, A.; Longworth, J.; Petrasch-Parwez, E. A Protein Quality Control Pathway Regulated by Linear Ubiquitination. The EMBO journal 2019, 38 (9).

Longworth, J.; Dittmar, G. Assessment of Ubiquitin Chain Topology by Targeted Mass Spectrometry. Methods Mol. Biol. 2019, 1977, 25–34. https://doi.org/10.1007/978-1-4939-9232-4_3.

Kaneva, I. N.; Longworth, J.; Sudbery, P. E.; Dickman, M. J. Quantitative Proteomic Analysis in Candida Albicans Using SILAC-Based Mass Spectrometry. PROTEOMICS 2018, 18 (5–6), 1700278. https://doi.org/10.1002/pmic.201700278.

Cartwright, J. F.; Anderson, K.; Longworth, J.; Lobb, P.; James, D. C. Highly Sensitive Detection of Mutations in CHO Cell Recombinant DNA Using Multi‐parallel Single Molecule Real‐time DNA Sequencing. Biotechnology and Bioengineering 2018. https://doi.org/10.1002/bit.26561.

Helliwell, K. E.; Pandhal, J.; Cooper, M. B.; Longworth, J.; Kudahl, U. J.; Russo, D. A.; Tomsett, E. V.; Bunbury, F.; Salmon, D. L.; Smirnoff, N.; et al. Quantitative Proteomics of a B12‐dependent Alga Grown in Coculture with Bacteria Reveals Metabolic Tradeoffs Required for Mutualism. New Phytologist 2018, 217 (2), 599–612. https://doi.org/10.1111/nph.14832.

Longworth, J.; Wu, D.; Huete-Ortega, M.; Wright, P. C.; Vaidyanathan, S. Proteome Response of Phaeodactylum Tricornutum, during Lipid Accumulation Induced by Nitrogen Depletion. Algal Research 2016, 18, 213–224. https://doi.org/10.1016/j.algal.2016.06.015.

González, J.; Longworth, J.; James, D. C.; Lawrence, N. D. Bayesian Optimization for Synthetic Gene Design. arXiv preprint arXiv:1505.01627 2015.

Longworth, J.; Noirel, J.; Pandhal, J.; Wright, P. C.; Vaidyanathan, S. HILIC- and SCX-Based Quantitative Proteomics of Chlamydomonas Reinhardtii during Nitrogen Starvation Induced Lipid and Carbohydrate Accumulation. J. Proteome Res. 2012, 11 (12), 5959–5971. https://doi.org/10.1021/pr300692t.