Selected Publications

 

- Thomas MH, Gui Y, Garcia P, Karout M, Gomez Ramos B, Jaeger C, Michelucci A, Gaigneaux A, Kollmus H, Centeno A, Schughart K, Balling R, Mittelbronn M, Nadeau JH, Sauter T, Williams RW, Sinkkonen L, Buttini M (2021) Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain (COL4A6) as a novel regulator of striatal axonal branching in mice. Genes, Brain and Behavior 28:e12769

- Oudin A, Baus V, Barthelemy V, Fabian C, Klein E, Dieterle M, Wantz M, Hau AC, Dording C, Bernard A, Michelucci A, Yabo YA, Kanli G, Keunen O, Bjerkvig R, Niclou SP, Golebiewska A (2021) Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors. STAR Protocols 2(2):100534

- Birck C, Ginolhac A, Pavlou MAS, Michelucci A, Heuschling P, Grandbarbe L (2021) NF-kB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells. Cells 10:840

- Uriarte Huarte O, Richart L, Mittelbronn M, Michelucci A (2021) Microglia in Health and Disease: The Strength to Be Diverse and Reactive. Frontiers in Cellular Neuroscience 15:660523

- Uriarte Huarte O, Kyriakis D, Heurtaux T, Pires-Afonso Y, Grzyb K, Halder R, Buttini M, Skupin A, Mittelbronn M, Michelucci A (2021) Single-Cell Transcriptomics and in Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway. Frontiers in Immunology 12:639613

- Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP (2020) Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica 140(6):919-49

- Gui Y, Thomas MH, Garcia P, Karout M, Halder R, Michelucci A, Kollmus H, Zhou C, Melmed S, Schughart K, Balling R, Mittelbronn M, Nadeau JH, Williams RW, Sauter T, Buttini M, Sinkkonen L (2020) Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging. Frontiers in Genetics 11:566734

- Pires-Afonso Y, Niclou SP, Michelucci A (2020) Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma. International Journal of Molecular Sciences 21(3):689

- Dirkse A, Golebiewska A, Buder T, Nazarov PV, Muller A, Poovathingal SK, Brons NHC, Leite S, Sauvageot N, Sarkisjan D, Seyfrid M, Fritah S, Stieber D, Michelucci A, Hertel F, Herold-Mende C, Azuaje F, Skupin A, Bjerkvig R, Deutsch A, Voss-Böhme A, Niclou SP (2019) Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. Nature Communications 10(1):1787

- Pavlou MAS, Grandbarbe L, Buckley NJ, Niclou SP, Michelucci A (2019) Transcriptional and epigenetic mechanisms underlying astrocyte identity. Progress in Neurobiology 174:36-52

- Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJV, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, ter Horst R, Joosten LAB, Wijmenga C, Hartley RC, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG (2019) The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. Cell Metabolism 29(1):211-20

- Sousa C, Golebiewska A, Poovathingal SK, Kaoma T, Pires-Afonso Y, Martina S, Coowar D, Azuaje F, Skupin A, Balling R, Biber K, Niclou SP, Michelucci A (2018) Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Reports 19(11):e46171

- Michelucci A, Mittelbronn M, Gomez-Nicola D (2018) Microglia in health and disease: A unique immune cell population. Frontiers in Immunology 9:1779

- Ravichandran S, Michelucci A, del Sol A (2018) Integrative computational network analysis reveals site-specific mediators of inflammation in Alzheimer’s disease. Frontiers in Physiology 9:154

- Sousa C, Biber K, Michelucci A (2017) Cellular and molecular characterization of microglia: a unique immune cell population. Frontiers in Immunology 8:198

- Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM (2016) Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels. Journal of Biological Chemistry 291(27):14274-84

- Tallam A, Perumal TM, Antony PM, Jäger C, Fritz VJ, Vallar L, Balling R, del Sol A, Michelucci A (2016) Gene regulatory network inference of immunoresponsive gene 1 (IRG1) identifies interferon regulatory factor 1 (IRF1) as its transcriptional regulator in mammalian macrophages. PloS One 11(2):e0149050

- Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, Fouquier D'Herouel A, Dong X, Weindl D, Stautner K, Nonnenmacher Y, Michelucci A, Giesert F, Schidknecht S, Kramer L, Schneider JG, Woitalla D, Wurst W, Skupin A, Vogt-Weisenhorn DM, Krüger R, Leist M, Hiller K (2016) Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease 89:112-125

- Gabel S, Koncina E, Dorban G, Heurtaux T, Birck C, Glaab E, Michelucci A, Heuschling P, Grandbarbe L (2016) Inflammation promotes a conversion of astrocytes into neural progenitor cells via NF-kB activation. Molecular Neurobiology 53(8):5041-55

- Michelucci A*, Bithell A*, Burney M, Johnston CE, Wong KY, Teng SW, Desai J, Gumbleton N, Anderson G, Stanton L, Williams BP, Buckley NJ (2016) The neurogenic potential of astrocytes is regulated by inflammatory signals. Molecular Neurobiology 53(6):3724-39

- Birck C, Koncina E, Heurtaux T, Glaab E, Michelucci A, Heuschling P, Grandbarbe L (2015) Transcriptomic analyses of primary astrocytes under TNFα treatment. Genomics Data 7:7-11

- Cordes T*, Michelucci A*, Hiller K (2015) Itaconic acid: The surprising role of an industrial compound as a mammalian antimicrobial metabolite. Annual Review of Nutrition 35:451-73

- Jäger C*, Glaab E*, Michelucci A*, Binz T, Koeglsberger S, Garcia P, Trezzi JP, Ghelfi J, Balling R, Buttini M (2015) The mouse brain metabolome: region-specific signature and response to excitotoxic neuronal injury. The American Journal of Pathology 185(6):1699-712

- Michelucci A*, Cordes T*, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K (2013) Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America 110(19):7820-5

- Wegner A, Cordes T, Michelucci A, Hiller K (2012) The application of stable isotope assisted metabolomics in biomedicine. Current Biotechnology 1(1):1-2

- Heurtaux T, Michelucci A, Losciuto S, Gallotti C, Felten P, Grandbarbe L, Morga E, Heuschling P (2010) Amyloid-beta conformation-dependent microglial activation: involvement of the FPR2 receptor. Journal of Neurochemistry 114(2):576-86

- Michelucci A, Heurtaux T, Grandbarbe L, Morga E, Heuschling P (2009) Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-beta. Journal of Neuroimmunology 210(1-2):3-12

- Grandbarbe L, Michelucci A, Heurtaux T, Hemmer K, Morga E and Heuschling P (2007) Notch signaling modulates the activation of microglial cells. Glia 55(15):1519-30

- Hauss F, Liu J, Michelucci A, Coowar D, Morga E, Heuschling P and Luu B (2007) Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation. Bioorganic & Medicinal Chemistry Letters 17:4218-22

* These authors contributed equally to this work