The actin cytoskeleton in tumor invasion and metastasis

In this project we explore the mechanisms by which tumor cells acquire an invasive phenotype, migrate out of the primary tumor and establish distant metastases.

The actin cytoskeleton in tumor immune evasion

Recently, we established the pivotal role of the actin cytoskeleton in tumor cell resistance to cytotoxic lymphocytes. We found that resistant tumor cells assemble a multifunctional “shield of actin..